Core Facilities and Service Centers

Core Facilities or Service Centers are centralized shared research resources that provide access to instruments, technologies, services, and in many cases expert consultation and training to researchers. Across the Institute, there are more than 50 core facilities. 

Core facilities generally recover their cost, or a portion of their cost, in the form of user fees that are charged to an investigator's grant, contract or, in some cases, discretionary funds. Because of this, they are subject to the Service Center Policy and associated Accounting and Operating Procedures

Many of these facilities are available on a fee-for-service basis to all investigators. Others are supported by individual departments, specific grants or groups of investigators, and may also be available on a fee-for-service to the broader community when capacity permits, or on a collaborative basis. 

Please send additions or updates to this listing to vpr-webmaster@mit.edu

Function Facility Location Description
Animal modeling and clinical testing
Animal modeling and clinical testing Zebrafish Core Facility 76-044 The KI Zebrafish Core Facility was established to provide expertise to KI and MIT researchers who wish to utilize zebrafish as a model organism for any kind of research along with professional daily care of the animals and aquarium systems. The facility can meet a wide range of needs, from one-off experiments of limited scope, to long-term maintenance of dozens of transgenic and/or mutant lines.
Animal modeling and clinical testing ES Cell & Transgenic Animal Core Facility 76-195 This shared resource of the Koch Institute provides fee-for-service support to all MIT investigators who utilize cultured ES cells or novel mouse models to study human diseases such as cancer. Services encompass embryonic stem cells, microinjections, repositories of reagent mice, and much more.
Cell Culture and Analysis
Cell Culture and Analysis ES Cell & Transgenic Animal Core Facility 76-195 This shared resource of the Koch Institute provides fee-for-service support to all MIT investigators who utilize cultured ES cells or novel mouse models to study human diseases such as cancer. Services encompass embryonic stem cells, microinjections, repositories of reagent mice, and much more.
Cell Culture and Analysis The Hope Babette Tang (1893) Histology Facility 76-182 The Hope Babette Tang (1983) Histology Facility has been established to assist the investigator in producing quality histological slides. Provides equipment and expertise to produce sections from frozen, paraffin-embedded, and resin-embedded tissues. Can produce routine hematoxylin and eosin stained slides and special stains, and can provide assistance to investigators performing immunohistochemistry, immunofluorescence and in-situ hybridization.
Cell Culture and Analysis IPS Core Facility 46-4277 Allowing researchers to directly examine a wide variety of diseases directly in human cells, the iPS facility in the BCS complex will provide a powerful incentive for different labs to collaborate together and exchange ideas. This common facility will integrate the various research goals of members of the Picower and McGovern Institutes, and the Department of Brain and Cognitive Sciences. The various BCS, McGovern, and Picower laboratories have expertise and experience with dfferent experimental protocols which, when combined in a collective manner to the study of human cells, will result in accelerated progress in this novel, dynamic and competitive field.
Cell Culture and Analysis Flow Cytometry Core Facility 76-279 (Cell Sorting Lab); 76-273 (Analysis) Provides KI and MIT researchers with technical expertise, training and access to sophisticated instrumentation, enabling and supporting the use of a wide range of flow cytometry techniques. This technology allows simultaneous multiparametric analysis of many thousands of cells per second, enabling trained researchers to rapidly analyze complex cell populations using benchtop analysis flow cytometers. High-speed assisted cell sorting services provide researchers with fast, objective and quantitative recording of fluorescent signals from individual cells combined with physical separation of cells of particular interest.
Cell culture and analysis High Throughput Screening Facility 76-047

The High Throughput Screening Facility provides automated screening capability to KI and MIT researchers, as well as access to curated small molecule and lentiviral shRNA (RNAi) libraries. The facility is equipped with an Arrayscan automated confocal high content screening microscope, Tecan Evo liquid handlers, plate washers, automated micoplate centrifuges, an automated plate reader, and automated CO2 incubators. The instruments can be used in either walk-up or automated modes using our robot arms for general screening or plate preparation.

The facility provides assay development and screening services in both BL2 and BL2+ space, as well as consultation and training for researchers with specific needs or challenging problems

Chemistry Synthesis and Analysis
Chemistry Synthesis and Analysis Biophysical Instrumentation Facility 68-470 The Biophysical Instrumentation Facility (BIF) houses instrumentation for aiding in the elucidation of macromolecular structure. It is largely used by researchers in Chemistry, Biology and BioEngineering but is available to anyone on campus and beyond. The BIF is a BL1 facility. It is staffed 40 hours a week by Debby Pheasant who is available to train new users and provide advice to anyone considering potential applications of the equipment in the facility.
Chemistry Synthesis and Analysis Biopolymers & Proteomics Core Facility 76-181 (Biopolymers); 76-387 (Proteomics) The Biopolymers & Proteomics Core Facility provides MIT researchers with integrated synthetic and analytical capabilities for biological materials, including DNA, proteins and nanoparticles. Services include routine Sanger DNA sequencing, mass spectrometry-based proteomics approaches for identification, characterization, or quantitation of proteins, MALDI-TOF mass spectrometry, peptide synthesis and purification, and high-pressure liquid chromatographic analysis and purification.
Chemistry Synthesis and Analysis Crystal Growth SEF 13-3120 The Crystal Growth shared experimental facility in the CMSE is a resource available to users within and outside of MIT community. Optical floating-zone furnaces, top-seeded growth furnaces, 3-zone tube furnace, box furnaces, arc melting furnace and cutting/polishing equipments to satisfy the needs of crystal growth. Facilities for characterization of crystals include SQUID magnetometers and ICP-AES. The project can be arranged as a contract to work or trained researchers to become qualified facility users.
Chemistry Synthesis and Analysis Department of Chemistry Instrumentation Facility 18-0090 The facility's function is to maintain a sufficient number and type of state-of-the-art major analytical instruments in order to support the ongoing research programs within the MIT Chemistry Department.
Chemistry Synthesis and Analysis Electron Microprobe Facility 54-1221; 54-1214 The MIT Electron Microprobe Facility serves as the centerpiece of analytical instrumentation used in EAPS for research and teaching activities in geochemistry, petrology and mineral physics. The instruments in the facility form part of the Center for Geochemical Analysis (CGA), which comprises six instrument-oriented facilities. The microprobe facility serves a broad spectrum of research scientists at MIT, Woods Hole Oceanographic Institution (WHOI), neighboring universities, academic institutions and the industry. Analytical services are available for the faculty and professionals. User training is also available. An hourly fee is charged.
Chemistry Synthesis and Analysis Francis Bitter Magnet Laboratory Building NW14 The objectives of CMR are: to develop sophisticated technologies for magnetic resonance in the areas of solution-state NMR, solid-state NMR, electron paramagnetic resonance (EPR), and dynamic nuclear polarization (DNP); to apply those technologies to biologically and medically significant research, both in-house and collaboratively; to operate a state-of-the-art instrument facility to serve needs of researchers in chemistry, biology, and medicine; and to openly disseminate and provide training in technological developments at the Center.
Chemistry Synthesis and Analysis ICPMS Facility   EAPS operates quadrupole and multicollector sector mass spectrometers under the direction of Professor Ed Boyle. These instruments use a high temperature argon plasma to ionize elements from aqueous and gaseous samples prior to mass spectrometric analysis.
Chemistry Synthesis and Analysis Instrumentation Facility (Dcif) 18-0090 The Department of Chemistry Instrumentation Facility is the shared instrument facility for the Chemistry Department located in the sub-basement of the Camille Edouard Dreyfus Building on the main MIT campus.  The facility's function is to maintain a sufficient number and type of state-of-the-art major analytical instruments in order to support the ongoing research programs within the MIT Chemistry Department.
Chemistry Synthesis and Analysis ISN Facility Service Center NE47-4F Founded in 2002, the ISN is a result of the Army’s vision to explore the potential power of nanotechnology to enable unprecedented advances in capabilities for Soldier protection and survivability. To capitalize on this opportunity, the Army decided to create the Institute for Soldier Nanotechnologies as a university center for basic research on nanotechnology. ISN equipment and facilities are available as resources to members of the MIT community.
Chemistry Synthesis and Analysis Laboratory Instruments and Electronics Service 18-393 Provides diagnosis, repair, modification, consultation, and education of laboratory equipment and electronic instrumentation in departmental laboratories.  Also provides access to analyltical instruments.  It is a resource specific to members of the Department of Chemistry.
Chemistry Synthesis and Analysis Laser Biomedical Research Center   Researchers use the LBRC's resources to exploit laser-based spectroscopic techniques for medical applications such as the spectral diagnosis of disease, investigation of biophysical and biochemical properties of cells and tissues and development of novel imaging techniques.
Chemistry Synthesis and Analysis Mass Spectrometry Lab   The current equipment includes an Applied Biosystems/Sciex QStar Elite quadrupole time-of-flight, an Agilent 1100 LC-MSD TOF, an Agilent 6430 triple quadrupole mass spectrometer, and - our newest instrument - an Agilent 6530 quadrupole time-of-flight with a 1290 Infinity UHPLC system.
Chemistry Synthesis and Analysis Materials Analysis SEF (Surface, Thermal, and Optical) 13-4111, 4137, 4139, and 4151 Analytical techniques available include Auger spectroscopy, X-ray photoelectron spectroscopy, atomic force microscopy, Quartz Crystal Microbalance with Dissipation, Thermal Analysis techniques and Profilometry. A wide array of spectroscopy techniques, including UV-visible-near IR spectrophotometry, Fourier transform infrared spectroscopy, Raman spectroscopy.
Chemistry Synthesis and Analysis Nanomechanical Technology Facility 8/1/39 12:00 AM A state-of-the-art laboratory in the Department of Materials Science and Engineering at MIT for probing the properties and surfaces of engineering and biological materials at atomic and molecular length scales through mechanical contact.
Chemistry Synthesis and Analysis Nuclear Reactor Laboratory Building NW12 The MIT Nuclear Reactor Laboratory (MIT-NRL) is an interdepartmental center that operates a high performance 6 MW research reactor known as the MITR-II. NRL staff also provide technical assistance for research projects for high school students, undergraduate and graduate students, university researchers and faculty members, and national laboratory users.
Chemistry Synthesis and Analysis High Throughput Screening Facility 76-047

The High Throughput Screening Facility provides automated screening capability to KI and MIT researchers, as well as access to curated small molecule and lentiviral shRNA (RNAi) libraries. The facility is equipped with an Arrayscan automated confocal high content screening microscope, Tecan Evo liquid handlers, plate washers, automated micoplate centrifuges, an automated plate reader, and automated CO2 incubators. The instruments can be used in either walk-up or automated modes using our robot arms for general screening or plate preparation.

The facility provides assay development and screening services in both BL2 and BL2+ space, as well as consultation and training for researchers with specific needs or challenging problems

Chemistry Synthesis and Analysis Structural Biology Core Facility 68-470 The Structural Biology Core Facility is open to the entire MIT community in structural biology and provides access to state-of-the-art equipment for X-ray crystallography.
Chemistry Synthesis and Analysis Viral Core Facility 46-6319 The viral gene transfer core's overall goals are to provide the most advanced viral vector technologies, and to drive the development of new applications that will benefit neuroscience research. The core currently offers HSV and BacMam vectors, including packaging, vector construction and advisory consultations. The core also offers AAV packaging through an external provider, Virovek, with whom the core has negotiated a discount. Operates as a fee-for-service facility.
Chemistry Synthesis and Analysis X-Ray Diffraction Facility 2-235 The MIT X-ray diffraction facility offers single crystal X-ray data collection, structure solution and refinement of small molecule structures (< 350 non-hydrogen Atoms). This includes the determination of the absolute configuration of chiral molecules from anomalous scattering.
Chemistry Synthesis and Analysis BioMicro Center 68-316 The BioMicro Center was founded as the core biofabrication and microarray processing facility at MIT, offering a wide range of genomic services to researchers. Majority of services rendered pertain to massively parallel sequencing using the Illumina platform, commercial array processing, real-time PCR, and informatics and computational support.
Chemistry Synthesis and Analysis CBE Core Facilities NE47, 3rd floor Applied Biosystems 7900HT 384-well plate qPCR Facility; Biacore (Surface Plasmon Resonance) Facility; Cressington Quick Freeze-Deep Etch EM Prep Facility; Multiphoton Microscopy Facility; Alpha Innotech Gel Imaging Facility
Chemistry Synthesis and Analysis Peterson (1957) Nanotechnology Materials Core Facility 76-037 The Peterson (1957) Nanotechnology Materials Core Facility provides a broad range of equipment and expertise to work with nanomaterials for the purposes of both characterization and imaging. Core imaging capabilities include a high performance field emission transmission electron microscope equipped for STEM, EELS, EDS and cryo-imaging, cryo-sample preparation, a freeze fracture system, and an atomic force microscope. Instrumentation for material characterization includes high throughput particle sizing, HPLC and dedicated nucleic acid HPLC, dynamic mechanical analysis, and rheometry.
Data Analysis
Data Analysis The Barbara K. Ostrom (1978) Bioinformatics & Computing Facility 76-158; 68-317a The Barbara K. Ostrom (1978) Bioinformatics & Computing Facility provides Koch Institute researchers with assistance and training in a wide range of bioinformatics related topics. Access is typically reserved for KI members. In some circumstances, access may be available to non-member MIT users. Examples include assistance with experimental design and subsequent analysis of next-generation sequencing and microarray experiments, genome annotation projects and other sequence and phylogenetic analysis applications. The Core also provides KI members with critical data backup as well as installation and maintenance of desktop hardware and a variety of software, including scientific applications.
Data Analysis Bioinformatics Resource Office 46-2303L The Picower Institute's Bioinformatics Office has been developed to utilize high-performance computing clusters to support high throughput data analysis, with a particular focus on genomic and epigenomic data analysis to support bench biologists.
Fabrication
Fabrication Central Machine Shop 38-001 The Central Machine Shop provides convenient, flexible and cost effective machine shop services to the MIT research community and acts as a clearing house for sending appropriate jobs to external shops. The Central Machine Shop personnel will work from a spectrum of rough sketches to machine drawings to create the machined product you require. Requests for shop services can be done either in person or from the Central Machine Shop webpage. Email can be sent directly to the Central Machine Shop at cmshop@mit.edu.
Fabrication Digital Design and Fabrication Group N51-328 The Design Fabrication Group is a center for education and research in areas of rapid prototyping and CAD/CAM fabrication for architects and designers. The group engages faculty, students and staff in research focused on the relationship between design computing and physical output used for design representation and reflection.
Fabrication Lab For Engineering Materials (LEM)   The LEM includes a variety of prototyping and machining equipment available to DMSE  for fabrication of experimental equipment, sample preparation, and general machining needs.
Fabrication Laboratory For Advanced Materials (LAM) 8-102 The Laboratory for Advanced Materials (LAM) is in 8-102. It is a shared facility, designed for flexible use. Some lab subjects meet in the LAM.
Fabrication Microsystems Technology Laboratories Facilities 39 The Microsystems Technology Laboratories microfabrication facilities include three cleanroom labs, which offer varying degrees of flexibility and cleanliness levels: Integrated Circuits Laboratory (ICL) -CMOS-compatible processes; Technology Research Laboratory (TRL)- CMOS-compatible plus opto-electronics, MEMS and other semiconductor processes; Exploratory Materials Laboratory (EML) - flexible processes on many materials; and Electron-beam Lithography facility (EBL) - enables writing patterns of arbitrary geometries with minimum features sizes as fine as 5 nm. MTL’s fabrication facilities are open to all MIT faculty and students, as well as users from other academic institutions.
Fabrication Scanning Electron Beam Lithography (SEBL) Facility 38-177 The scanning-electron-beam lithography (SEBL) facility enables the writing of patterns of arbitrary geometries with minimum features as fine as 17 nm.
Human Subjects Testing
Human Subjects Testing IMES Clinical Research Center E25, 2nd floor The Harvard Catalyst Clinical Research Center at MIT (HCCRC@MIT), a member of the Harvard Catalyst Clinical and Translational Science Center, is an interdisciplinary clinical center that serves MIT scientists and engineers involved in clinical research. We promote and support the translation of progress in basic science into advances in patient-oriented clinical research. The Center has two main branches: the Biomedical and Behavioral units.
Imaging: Animal Modeling and Clinical Testing
Imaging:  Animal Modeling and Clinical Testing Animal Imaging & Preclinical Testing Core Facility 76-188 The Applied Therapeutics and Whole Animal Imaging Core Facility's primary goal is to support and encourage the translational efforts using refined mouse models of human cancers to test chemotherapeutic response and drug resistance, biosensors for tumor detection and monitoring, diagnostics assays, cancer vaccines, drug delivery systems, and tumor-targeted modalities. Also provides access to instrumentation for in vivo, whole animal imaging, including bioluminescence, fluorescence, ultrasound, and microCT tecnologies.
Imaging
Imaging Electron Microscopy SEF 13-1012 Transmission Electron Microscopy (TEM) allows the researcher to form images of thin slices or nano particles of samples at a resolution of down to 0.14 nm (lattice resolution). Crystal structure may be analyzed by means of electron diffraction, and chemical analysis, with a sensitivity (in ideal cases) of a few atoms and spatial resolution (again, in ideal cases) of about 0.5nm, may be performed by energy-dispersive X-ray spectroscopy (EDS) analysis or electron energy-loss spectroscopy (EELS) analysis. The Scanning Electron Microscope (SEM) is a tool for visualizing the surface of solid samples, with a resolution (depending on the application) that can approach 1nm. Energy-dispersive X-ray analysis can be used to analyze volumes with dimensions of around 1 micron with a sensitivity of about 0.2wt%, while back-scattered electron imaging allows the visualization of regions of different composition. Crystallographic orientation and structure can be examined using electron backscatter diffraction (EBSD) analysis, though sample preparation requirements for this technique are very stringent and limit the number of samples that can be studied in this way.
Imaging Martinos Imaging Center 46-1171 The Martinos Imaging Center is a core facility that provides access to state-of-the-art brain imaging technologies for MIT researchers and their collaborators, including human MRI, small-animal MRI, EEG and MEG. Major research themes at the center include: brain mechanisms of perception, memory, emotion, executive function and social cognition; developmental studies of children; and translational studies on the neural basis of many different psychiatric and neurological disorders.
Imaging Microscopy Core Facility 76-281 The Microscopy Core Facility provides experimental consultation, fee-for-service imaging assistance, and training in and access to several imaging platforms, image acquisition equipment and data analysis software packages. Services include light and epifluorescence microscopy, deconvolution-based microscopy, spinning disk confocal microscopy, total internal reflection fluorescence microscopy, spectral karyotyping and fluorescent in situ hybridization, laser capture microdissection, and standard transmission electron and immunoelectron microscopy.
Imaging W.M. Keck Microscopy Facility Whitehead Institute, Room 447 Provides state of the art instrumentation and technical expertise to generate and interpret microscopic images; assists investigators in applying sophisticated microscopy techniques to their research; and trains researchers in microscopy techniques and methodology.
Instrument Repair
Instrument Repair Laboratory Instruments and Electronics Service 18-393 Provides diagnosis, repair, modification, consultation, and education of laboratory equipment and electronic instrumentation in departmental laboratories. Also provides access to analytical instruments. It is a resource specific to members of the Department of Chemistry.
Materials Production and Analysis
Materials Production and Analysis ISN Facility Service Center NE47-4F Founded in 2002, the ISN is a result of the Army’s vision to explore the potential power of nanotechnology to enable unprecedented advances in capabilities for Soldier protection and survivability. To capitalize on this opportunity, the Army decided to create the Institute for Soldier Nanotechnologies as a university center for basic research on nanotechnology. ISN equipment and facilities are available as resources to members of the MIT community.
Materials Production and Analysis Materials Analysis SEF (Surface, Thermal, and Optical) 13-4111, 4137, 4139, and 4151 Analytical techniques available include Auger spectroscopy, X-ray photoelectron spectroscopy, atomic force microscopy, Quartz Crystal Microbalance with Dissipation, Thermal Analysis techniques and Profilometry. A wide array of spectroscopy techniques, including UV-visible-near IR spectrophotometry, Fourier transform infrared spectroscopy, Raman spectroscopy.
Materials Production and Analysis Nanomechanical Technology Facility 8/1/39 12:00 AM A state-of-the-art laboratory in the Department of Materials Science and Engineering at MIT for probing the properties and surfaces of engineering and biological materials at atomic and molecular length scales through mechanical contact.
Materials Production and Analysis Telams Facility Use 33-322 These areas include multi-scale modeling and simulation of the mechanics of advanced materials used in the aerospace industry with emphasis on understanding the influence of micro-structural features of deformation and failure in their effective engineering response, computational modeling in solid mechanics, and design, fabrication, and testing of micro-electromechanical systems (MEMS), along with their associated materials and processes.
Materials Production and Analysis Ceramics Processing Research Laboratory 12-011 The CPRL is a central facility with a wide range of analytical and ceramics processing equipment. Provides services for members of the MIT community and outside users. The CPRL is also home to Michael Cima's research group. Currently investigating a number of interesting research areas, including advanced drug delivery techniques and high temperature superconductivity.
Materials Production and Analysis Peterson (1957) Nanotechnology Materials Core Facility 76-037 The Peterson (1957) Nanotechnology Materials Core Facility provides a broad range of equipment and expertise to work with nanomaterials for the purposes of both characterization and imaging. Core imaging capabilities include a high performance field emission transmission electron microscope equipped for STEM, EELS, EDS and cryo-imaging, cryo-sample preparation, a freeze fracture system, and an atomic force microscope. Instrumentation for material characterization includes high throughput particle sizing, HPLC and dedicated nucleic acid HPLC, dynamic mechanical analysis, and rheometry.
Materials Production and Analysis Thin Films Labs 8-140 Nocera Pulsed laser deposition system operating with a 248 nm wavelength excimer laser.
Technology R&D
Technology R&D Gas Turbine Laboratory 31-264 Research at the GTL is focused on advanced propulsion systems and turbomachinery with activities in computational, theoretical, and experimental study of: (1) loss mechanisms and unsteady flows in turbomachines, (2) compression system stability and active control, (3) heat transfer in turbine blading, (4) gas turbine engine noise reduction and aero-acoustics, (5) pollutant emissions and community noise, and (6) MEMS-based high-power-density engines.
Technology R&D Wright Brothers Wind Tunnel 17 MIT's Wright Brothers Wind Tunnel's primary use is for student projects, research and instruction, however it is also available for commercial research and development.
In addition to the usual force and moment balance system, this 7 X 10-foot elliptical cross-section wind tunnel has the necessary auxiliary equipment for inlet and diffuser testing, gust generation, and production of thick boundary layers to model the earth's boundary layer.
Technology R&D Marine Hydrodynamics Water Tunnel 3-269 This lab is dedicated to the study of all aspects of marine hydrodynamics. The main facility is a variable pressure recirculating water tunnel that is capable of speeds up to 10 m/s. Experiments with conventional and novel propulsion devices, drag reduction using MHD (magneto-hydrodynamics), flow control by unsteady swimming motion and flapping foils, offshore cylinder testing and vortex-induced-vibrations are performed using state of the art measurement techniques and instrumentation.
Technology R&D Ocean Engineering Testing Tank 48-015 The MIT Towing Tank is an experimental hydrodynamics testing facility consisting of a 100 ft x 8 ft x 4 ft testing tank with a functional wave maker and beach, and an 8 ft x 3 ft x 3 ft flow visualization tank.  The 100 ft long tank was originally used for ship model resistance testing, although it has been refitted to accomodate experiments associated with the study of biomimetics in marine creatures and vortex-induced vibrations, while maintaining the original model testing capabilities. The smaller visualization tank, consisting of a three axis motor system, and outfitted with a high-speed particle image velocimetry (PIV) system, is used primarily for the quantitative visualization of fluid flows.
Technology R&D Space Propulsion Laboratory 37-462 The Space Propulsion Laboratory (SPL) houses experimental facilities to support research and educational programs for MIT students. SPL provides the infrastructure to support the Space Propulsion graduate field in the Department of Aeronautics and Astronautics. A significant fraction of SPL's research is focused on the development and modeling of space thrusters.
Technology R&D Space Systems Laboratory 37-315 The SSL encompasses expertise in structural dynamics, attitude determination and control, avionics, communications, optical and RF payloads, systems engineering, and integrated modeling and simulation. These competencies are applied to the development of on-orbit test beds and small satellites with partners from across academia, industry, and government. The laboratory has various in-house facilities for the design, fabrication, integration, and test of flight hardware.
Technology R&D Synthetic Biology Center NE47-223 The mission of the Synthetic Biology Center at MIT is to develop and advance the engineering discipline for this emerging field, so that construction of novel biological systems can become a practical and useful engineering discipline.